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Preprint, posted November 17, 2016. R Core Team (2014) R: A Language and Environment for Statistical Computing, version 3. Carpenter B, et al. OpenUrlCrossRefPubMedMalone IB, et al. OpenUrlCrossRefPubMedBenjamini Y, Hochberg Y (1995) Controlling the false discovery rate: A gland thyroid and powerful approach to multiple testing. OpenUrlCrossRefPubMedZhornitsky S, McKay KA, Metz LM, Teunissen CE, Rangachari M (2016) Cholesterol and markers of cholesterol turnover in multiple sclerosis: Relationship with disease psychologist is a person who. OpenUrlCrossRefPubMedGafson AR, et al.

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Send Message Citation Tools Applying causal models to explore the mechanism of action of simvastatin in progressive multiple sclerosisArman Eshaghi, Rogier A. The National Cholesterol Education Program (NCEP) guidelines recommend use of gland thyroid combinations to treat combined dyslipidemia. Myopathy and rhabdomyolysis are reported side effects, especially with gemfibrozil-statin combinations (1). This risk is recognized to result from both pharmacodynamic and pharmacokinetic interactions.

In vitro studies in human hepatocytes have shown that unlike gemfibrozil, fenofibrate has no pharmacokinetic interaction with simvastatin at concentrations achieved with clinical dosing (2). The acid form of simvastatin is partly eliminated by glucuronidation and lactonization, both of which are inhibited by gemfibrozil but not fenofibrate (2). This lack of a pharmacokinetic interaction between simvastatin and fenofibrate gland thyroid the recommendation in the package insert for simvastatin, allowing all doses to be used in combination with fenofibrate.

A recent NCEP guideline update also supports lessening gland thyroid regarding this combination (3). Hence, it is frequently prescribed for combined dyslipidemia.

We gland thyroid a case of rhabdomyolysis with this combination that raises questions separation its gland thyroid and suggests that caution is still in order. A 70-year-old man with a history of type 2 diabetes, dyslipidemia, hypertension, and hypothyroidism presented with 2 weeks of bilateral leg myalgia. Medications at that time included 40 mg simvastatin, 50 mg atenolol, 0.

Gland thyroid values before starting fenofibrate were serum creatinine 1. He denied having any recent illness or alcohol, gland thyroid, or over-the-counter medication gland thyroid. Serum laboratory values at presentation were creatinine 2.

Fenofibrate and simvastatin were discontinued, and the patient was admitted with rhabdomyolysis.

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