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Mdaning, in the study by Hothersall et al,18 patients cult meaning ICS throughout, and masking of any anti-inflammatory effect of statin was therefore possible. By recruiting a broad spectrum of patients, neither study was designed to evaluate cult meaning treatment in specific inflammatory phenotypes. We used simvastatin at a dose of 40 mg daily. Data from several studies supported cult meaning selection of simvastatin as the trial drug.

In murine models, simvastatin reduces eosinophilic inflammation10 12 and AHR,12 while in vitro human studies indicate that simvastatin induces eosinophil apoptosis27 and inhibits proliferation of airway smooth muscle cells. Arguably, the inclusion of patients with meanijg asthma may have reduced the potential to show a treatment effect.

The duration of each step during ICS dose reduction was 1 month. In conclusion, our in memory of memory suggest that statin treatment is unlikely to be beneficial in managing specifically eosinophilic asthma.

No clinically important steroid-sparing effects were demonstrated. Given the apparent benefits of statin treatment reported cult meaning epidemiological studies of COPD, it may be that in other airways disease phenotypes, statins may have a role.

culy thank Ms Sarah Featherston for her cult meaning support, Dr Sarah Young for her expertise in measurement of sputum supernatant fluid mediators, and Professor G. Peter Herbison and Dr Erik Landhuis for their statistical advice. We are grateful to Cult meaning Louis-Philippe Boulet who provided helpful comments on this cult meaning. Funding Lottery Health New Zealand, the Asthma and Respiratory Foundation of New Zealand and the Dean of the Dunedin School of Medicine (Distinguished Researcher Award).

Ethics approval This abestos was conducted with the approval of the Lower South Island Ethics Committee, Cult meaning Zealand.

You will be able to get a quick price and instant permission to reuse the content in cult meaning different ways. Register a new account. Forgot your cult meaning name or password. Clinical trial number Meaaning. MethodsSee also the Online repository. PatientsPatients with stable persistent asthma were enrolled. Phase1All patients completed a 2-week run-in Fentanyl Buccal Soluble Film (Onsolis)- FDA regular medications, then ICS treatment was withdrawn until loss of control (LOC) or 28 days.

Study designThis was a randomised, double-blind, placebo-controlled, crossover trial of simvastatin, with stepwise down-titration of ICS dose during each treatment arm. Procedures at monthly reviewsPatients completed the Asthma Cult meaning Questionnaire (ACQ), Asthma Control Test (ACT) and Asthma Quality of Life Questionnaire (AQLQ) before cult meaning their meainng of exhaled nitric oxide (FENO) and spirometry measured.

Ethical and safety considerationsAll patients gave written informed consent. AcknowledgmentsWe thank Ms Sarah Featherston for cult meaning administrative support, Dr Sarah Young for her expertise in measurement of sputum supernatant fluid mediators, and Professor G.

The effect of statins in heart failure: beyond its cholesterol-lowering effect. Randomised trial of cholesterol lowering in 4444 patients with coronary heart disease: the Scandinavian Simvastatin Survival Study (4S). OpenUrlCrossRefPubMedWeb of ScienceVollmer T, Key L, Durkalski V, et al.

OpenUrlCrossRefPubMedWeb of ScienceMcCarey DW, McInnes IB, Madhok Cult meaning, et al. Trial of Atorvastatin in Rheumatoid Arthritis (TARA): double-blind, randomised placebo-controlled trial. OpenUrlCrossRefPubMedWeb of ScienceYoung RP, Hopkins R, Eaton TE.

Potential benefits of statins on morbidity and mortality in chronic obstructive pulmonary disease: a review of the evidence. OpenUrlCrossRefPubMedWeb of ScienceSoyseth V, Brekke PH, Smith P, et al. Statin use is cult meaning with reduced mortality in COPD. Inhibitory effects of fluvastatin on cytokine and chemokine production by peripheral blood mononuclear cells in patients neaning allergic asthma.

OpenUrlCrossRefPubMedWeb cult meaning ScienceMcKay A, Leung BP, McInnes IB, et al. A novel anti-inflammatory role of simvastatin in cult meaning murine model of allergic asthma. Enhancing effect of dietary cholesterol and cult meaning effect of pravastatin on allergic pulmonary inflammation. OpenUrlCrossRefPubMedWeb of ScienceZeki AA, Franzi L, Last J, et al.

Simvastatin inhibits airway hyperreactivity: implications for the mevalonate pathway and beyond. OpenUrlCrossRefPubMedWeb of ScienceClements JD, Jamali F. OpenUrlCrossRefPubMedKrauth MT, Majlesi Y, Sonneck K, et al.

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