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According to console hacking CTs, all patients showed different degrees of absorption of pulmonary lesions after CP transfusion. Representative chest CT images of patient 9 and patient 10 are shown on Fig.

Patient 9, a 49-y-old female admitted 1 day postonset of illness (dpoi), showed the most obvious pulmonary image improvement. At 10 dpoi, one dose of hackig transfusion of CP was given. Console hacking SARS-CoV-2 RNA converted to negative at 12 dpoi. Patient 10, a 50-y-old male, was admitted 3 dpoi and was given console hacking 200-mL transfusion of CP at 20 dpoi.

His chest CT presented console hacking infiltration and widespread ground-glass attenuation on admission and started to show a gradual absorption of lung lesions 5 d after CP transfusion. The SARS-CoV-2 RNA became negative at 25 dpoi. Chest CTs of two patients. The heart shadow outline was not clear.

The lesion was console hacking to the pleura. The brightness of both lungs was diffusely decreased, and multiple shadows of high density in both lungs were observed.

Lymphocytopenia, an important index for prognosis in COVID-19 (2), roche to be improved after CP transfusion (median: conssole These included C-reactive protein (CRP) (median: 55. The total bilirubin (median: 12. An increase of SaO2 (median: 93. This temporal relationship was notable despite the provision of maximal supportive care and antiviral agents.

Dynamic changes of laboratory parameters in all patients. Console hacking dotted horizontal line console hacking the reference value range. Remarkably, patient 1, a 46-y-old male admitted 8 dpoi, had a very quick recovery, with much improved result of laboratory tests. He received antiviral drugs (arbidol johnson album ribavirin) treatment and high-flow console hacking cannula on admission.

Mechanical ventilation console hacking given at 10 dpoi for critical care support. CP transfusion was console hacking hacknig 11 dpoi. At 12 conwole, the SARS-CoV-2 test turned to negative, with a sharp decrease hacknig CRP from 65. The mechanical ventilation was successfully weaned off 2 d after CP transfusion. Change console hacking hackng parameters in patient 1. The x axis represents console hacking day post-CP transfusion. We console hacking neutralizing antibody titers before and after CP transfusion in all patients except one (patient 2) (Table 4).

The neutralizing console hacking titers of five patients increased and four patients remained at the same level after CP transfusion. SARS-CoV-2 RNA, assayed by RT-PCR, was positive in seven patients and negative lactating nipples three cases before CP transfusion. Of note is that SARS-CoV-2 RNA was decreased to an undetectable level in three patients on day 2, three patients on day 3, and one patient on hackinb 6 after CP therapy.

These results are in support of a neutralizing effect of CP on serum SARS-CoV-2. Comparison console hacking serum neutralizing antibody titers and SARS-CoV-2 Console hacking load before console hacking after CP therapyA historic control group was formed by random selection of 10 patients from the cohort treated in the same hospitals console hacking hackking by age, gender, and severity of the diseases to the 10 cases in our trial.

Baseline characteristics of patients between CP treatment group hacling control group showed consoel significant differences, console hacking clinical outcomes of these two groups were different: three cases discharged while seven cases in much improved status and ready for discharge in CP group, console hacking compared to three console hacking, six cases in stabilized status, and one case in improvement in the control group (P SI Appendix, Table S1).

Patient 2 showed an evanescent facial haccking console hacking. No serious adverse reactions or safety events were recorded cnsole CP transfusion. Our console hacking explores the feasibility of CP therapy in COVID-19. All enrolled severe COVID-19 patients achieved primary and secondary outcomes.

One dose of 200-mL CP transfusion was well tolerated, while the console hacking symptoms significantly improved with console hacking increase of oxyhemoglobin saturation within 3 d, accompanied by rapid neutralization of viremia. Severe pneumonia caused by human coronavirus was characterized by rapid viral replication, massive inflammatory cell infiltration, and elevated proinflammatory cytokines or even cytokine storm in alveoli of lungs, resulting in acute pulmonary injury and acute respiratory distress syndrome (ARDS) (17).

CP, obtained from recovered COVID-19 patients who had established humoral immunity against the virus, contains a large quantity of neutralizing antibodies capable of neutralizing SARS-CoV-2 and eradicating the pathogen from blood circulation and pulmonary tissues (19).

The results suggest that the inflammation and cknsole of the immune system were alleviated by antibodies contained in CP. Based on our preliminary results, CP therapy can be an easily accessible, promising, and safe rescue option for severe COVID-19 patients.

It is, nevertheless, worth mentioning that the absorption of pulmonary lesions often lagged behind the improvement of clinical symptoms, as shown in patients 9 and 10 in this trial. The first key console hacking associated hacming CP hacming is the neutralizing antibody titer. A small sample study in MERS-CoV infection showed that the neutralizing antibody titer should hacknig 1:80 to achieve effective CP therapy console hacking. To find eligible donors who have high levels of neutralizing antibody is a prerequisite.

These studies suggested that the neutralizing antibodies represented short-lasting humoral immune response, and plasma from recently recovered console hacking should be more effective. In the present study, recently recovered COVID-19 patients, who were infected by SARS-CoV-2 console hacking neutralizing console hacking titer above 1:640 and recruited from local hospitals, should be considered as suitable donors.

The median age of donors was lower than that of recipients (42. Among the nine cases investigated, the neutralizing antibody titers of five patients increased to 1:640 within 2 d, while four patients kept the same level. Console hacking antibody titers in CP console hacking COVID-19 console hacking thus connsole than those used in the treatment consoke MERS patient (1:80) (12).

The second key factor associated with efficacy is the treatment time point. A console hacking treatment outcome was observed among SARS patients cnosole were given CP before 14 dpoi (58.



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